5 comments

  • Spacecosmonaut3 hours ago
    I&#x27;m 35. I had a preventative colonoscopy done (I had to insist). I payed out of pocket since these checkups normally start at 50.<p>Adenoma found and removed.<p>This is a type of cancer that is almost entirely preventable with screening. Get your tubes checked.
    • jml781 hour ago
      I did the same at 42 due to my mom consistently having polyps. Insurance refused to cover. I was told I would have had cancer by 45 most likely.<p>Had no symptoms, now I get one every 5 years.
    • solids1 hour ago
      Wow, did you have any kind of symptoms?
    • hawk_3 hours ago
      Did you suspect you had a higher chance than general population? If so why?
      • Spacecosmonaut2 hours ago
        Not really. I try to live a pretty healthy lifestyle. I work as a cancer researcher, so I have more contact with these data.
        • hawk_2 hours ago
          That&#x27;s crazy. And you don&#x27;t deal with wet lab I imagine, so just a freak occurrence.
    • thin_carapace3 hours ago
      I don&#x27;t intend to disagree, merely to suggest that while doing the right thing one would be best off considering the potential aspects inflicted to themselves, in this case colonoscopy deaths are one in ten thousand from memory
      • Spacecosmonaut2 hours ago
        I suspect that risk calculus depends on where you live.
    • BrtByte1 hour ago
      [dead]
    • sevenzero3 hours ago
      I&#x27;d rather die over having a tube up my ass, and I&#x27;ve seen my father die to this exact type of cancer.
      • zfree1 hour ago
        To anyone wondering about this, I did it last year. You don&#x27;t remember the procedure at all, you&#x27;re just left with the blissful afterglow of the drugs they use to make you sleep. That stays with you for a couple of days. The uncomfortable part is the day before when you have to do a cleanse. Worth it.
        • DoingIsLearning52 minutes ago
          &gt; You don&#x27;t remember the procedure at all, you&#x27;re just left with the blissful afterglow of the drugs they use to make you sleep.<p>Technically this will vary depending on the protocol. I have friends in this field and in some countries they effectively knock you out with sedation. Others you might get some anxiety medication and only sedate elderly or uncollaborative patients.<p>Regardless of that everyone should absolutely get checked but just wanted to make sure we don&#x27;t set unrealistic expectations.
      • Spacecosmonaut2 hours ago
        I think its okay when you tell the doctor no homo.
        • ackbar032 hours ago
          I think you need to get the doctor to say it, not the other way round
        • sevenzero2 hours ago
          Surely
      • taskforcegemini2 hours ago
        not sure if that makes it better for you, but usually you are knocked out and don&#x27;t know what is happening during the procedure. Much worse is the preparation starting days before with disgustingly tasting things that intentionally give you diarrhea (and maybe make you puke) to clear the path, and no food at all
        • Findecanor1 hour ago
          People get a <i>safe</i> but vile-tasting laxative by default. If you don&#x27;t have any known problems with your colon then you could ask for a faster-acting laxative that is easier to get down.<p>I have a condition so I have a colonoscopy every year. Once I had found out about there being a fast-acting option, I&#x27;ve always chosen that.<p>I&#x27;ve never done it sedated. I prefer to watch the screen and and ask questions. I&#x27;ve found the view quite fascinating, actually. The doctors and nurses have always been professional, focused on the colon: not the butt. There is absolutely nothing sexual about it. I&#x27;ve never felt pain: only some tension, and that&#x27;s been because of gas (needed to get a clear view). It is perfectly safe unless your colon has some illness of some sort. The worst part has always been the prep.
        • sevenzero1 hour ago
          Yea I know, my life just isn&#x27;t worth living and I&#x27;d prefer not to have something shoved up my ass to prevent something that could end it early cuz I am too foolish to do it myself.
      • esikich1 hour ago
        I know it&#x27;s difficult, but you should truly engage these thoughts now and then. You&#x27;re pretty safe coming out in 2026, but it&#x27;s understandable if you&#x27;re worried about what your friends, family, and coworkers might think. Best thing you can do is just get real with yourself and admit <i>to yourself</i> that you are gay. The sooner you can end that internal struggle, the better.
        • sevenzero33 minutes ago
          If anything I am asexual, but idk why that matters here.
        • gurumeditations58 minutes ago
          What is this homophobic garbage? Stop. You are disgusting. Gay is not your insult. Shame on you romancist.
  • andai3 hours ago
    Does this track differences between generations (i.e. environmental changes), or the age-related differences within a single cohort, or somehow both at once?
  • cobaltpath6 hours ago
    I wonder if the higher proportion of stromal cells in young tumors is a direct result of specific dietary components or gut microbiome variations rather than just inherent biology. The study mentions looking at how cell programs interact with diet and microbes, but it seems early onset cases often present with distinct inflammatory profiles in the colon itself before tumor formation.<p>It would be interesting to see if these long non-coding RNAs show up consistently in pre cancerous polyps in younger patients or only after malignant transformation. If they are elevated early on, that could actually help solve the diagnosis problem where many late stage cancers are found, assuming we can target them specifically.
    • yread3 hours ago
      The lncRNA is common in all CRCs but the stroma content in healthy tissue usually increases with age
  • BrtByte1 hour ago
    [dead]
  • 48484995553 minutes ago
    Its anal, sorry this is haram to publish T. Postdoc