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Meanwhile someone went and did the experiment on the equivalent problem in a virus: <a href="https://www.science.org/content/blog-post/mutate-em-all-and-see-if-you-can-sort-em-out" rel="nofollow">https://www.science.org/content/blog-post/mutate-em-all-and-...</a>
the catch with a genome-wide map is the benchmark labels came from conservation, so you can't tell prediction from re-reading the prior.
Some more discussion: <a href="https://news.ycombinator.com/item?id=49611251">https://news.ycombinator.com/item?id=49611251</a>