Always love reading Derek Lowe's writings. One thing confused me, though:<p>>These authors find that it has potent activity against the ion channel TRPM8, and that goes for other 7-nitro compounds in this series as well.<p>But later states<p>>For one thing, the other benzodiazepines aren’t much use; clonazepam really stands out on its own.<p>Wouldn't another 7-nitro compound also work? Flunitrazepam/Rohypnol, for example? A little bit of research shows it actually might[1].<p>[1] <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC13426060/" rel="nofollow">https://pmc.ncbi.nlm.nih.gov/articles/PMC13426060/</a>