Hamilton's Pharmacopia covers this topic, including an interview with the supposed author, then later corrected, then the true author revealed. Definitely worth checking out.
Every time I find one of these in my backyard with my dog, I have to spray my dog’s mouth out with the hose for 5 minutes. Psychedelic, but also very toxic.
Just my local regular non hallucinogenic toads makes dogs drewl like crazy if they try to catch on (or more commonly find a toad chip road kill on the gravel roads)
Reminds me of the datura all over my yard. I keep chopping them down (while wearing gloves) but they keep coming back.<p>They're pretty but definitely a "look, don't eat" plant.
I've tried this before and it was an incredibly profound experience. Happy to answer questions if folks have any.
Have any studies been done on this particular psychedelic? I'm curious.
A couple groups are trying to commercialize it. There have been some trials, but they're all relatively limited by depression trial standards. Double-blind is impossible because the participants know 100% if they've received it or not. Someone volunteering to sign up for a depression study to receive psychedelic drugs is probably a believer that they work, so the placebo groups end up disappointed and the active groups are happy they got assigned the psychedelic they signed up.<p>One of the latest studies: <a href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2846834" rel="nofollow">https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...</a><p>They followed participants for 8 days, which is pretty disappointing. They really need to follow people for several months to see if anything holds or if it's a short-term placebo effect that wears off.
It's 5-MeO-DMT, better to synthesize it than to exploit the toads for it though.<p><a href="https://youtu.be/qipKKBmY_LQ" rel="nofollow">https://youtu.be/qipKKBmY_LQ</a>
<a href="https://en.wikipedia.org/wiki/5-MeO-DMT" rel="nofollow">https://en.wikipedia.org/wiki/5-MeO-DMT</a> has some references and the "further reading" links might have way more
plenty of scientific and not-really-scientific links available at erowid for 5-meo-dmt<p><a href="https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml" rel="nofollow">https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml</a><p>scientific references specifically at <a href="https://www.erowid.org/references/refs.php?S=5meo_dmt" rel="nofollow">https://www.erowid.org/references/refs.php?S=5meo_dmt</a>
Most recent I know of: <a href="https://www.psychiatrictimes.com/view/blp-003-for-treatment-resistant-depression-phase-2b-patient-enrollment-completed" rel="nofollow">https://www.psychiatrictimes.com/view/blp-003-for-treatment-...</a><p>Mebufotenin is 5-MeO-DMT
Completely fascinating video on this topic just recently:<p><a href="https://www.wsj.com/video/the-race-to-commercialize-the-worlds-most-powerful-psychedelic/F24E9B22-38D3-4BFC-B80A-3B5F73423E0C" rel="nofollow">https://www.wsj.com/video/the-race-to-commercialize-the-worl...</a>
I'm guessing this is here because it was featured on an episode of Beef Season 2 from Netflix.
Recently published, curious if anyone has read it:
<a href="https://www.penguinrandomhouse.com/books/735472/the-ego-trip-by-kimon-de-greef/" rel="nofollow">https://www.penguinrandomhouse.com/books/735472/the-ego-trip...</a>
<i>Find your soulmate, Homer!</i>
Can we please leave the fucking toads alone?<p>This is an endangered species getting massively abused by the wellness "shaman" industry. It fucking sucks. Just use synthetic 5me0-dmt if you really must do a goofy vision quest larp.
Hmm. I am all for leaving animals alone, but their Wikipedia page says their status is “secure” and of “least concern”.<p>So yeah, let the frogs be, but I don’t think we should invent (hallucinate, in this case, perhaps?) reasons why…
People really overthink drugs.<p>You don't need anything more than psilocybin and some weed from time to time.<p>Anything else is just unnecessary noise and introduces vulnerabilities to your Fortress of Mind.<p>Backdoor here, trapdoor here, tunnel there. Before you know it, your psyche collapses under all the brain neuroplasticity. Mind cannot form any shape at all.<p>Truly terrible thought so be careful my people. Don't malleableize yourself into a goo.
I’ve used both a lot.<p>It’s inaccurate to frame weed and psilo as “necessary”.
YMMV by person, their neurochemistry, and their living environment. I need a stimulant for my specific biology to adapt to modern expectations.
You don't need anything.<p>It is the bilion dollar industrial complex that sold you solution to the problem created by the very same system. Just take a pill.<p>It's ingenious really.<p>Create the problem, sell the solution.<p>I am rich generally speaking and I have privilege to see everything from my high vantage point.
From here I can easily see how life looks if you can afford to say: No thank you.<p>I don't even understand the very concept of suicide or depression. It seems fantastical. Because, I am outside the cruel system or rather I am at the steer in some capacity.
this post just demonstrates the lack of sympathy/empathy so many rich people seem to have for others. There is a huge difference between taking pills designed to eternally treat symptoms and never the root cause, vs a plant medicine that might actually address the root cause of a problem. Bufo unfortunately has the added problem of coming from an animal rather than a plant, I agree with another post that suggests using synthetic where possible, but one should also not give up the opportunity to do life-changing personal development...
> understands people and knows what people need<p>> does not understand the concept of [incredibly common psychological problem]
Your comment isn’t useful to anyone but you
The type of mind that could genuinely benefit from a psychedelic…
hmmm; I really don’t feel like I need weed or shrooms from time to time. I’m ok the way I am.
HAMILTON,BUFOTENINE YOU NEED TO MAKE A VIDEO. xD<p>Anyone watch Hamiltons pharmacopeia