> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks.<p>"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:<p>> Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.<p>Cool! But please be honest in your press releases.
Ok, I've inmiced the title above. Thanks for catching this.
ctrl+f'd for 'mice', no results. I can think of no other word than deceit.
I always interpret the rule [0] "Otherwise please use the original title, unless it is misleading or linkbait; don't editorialize." to be referring to a story like this one.<p>Adding the words [in mice] would not only be the acceptable exception the rule is referring to but probably necessary. This would align the title properly with the article contents and avoid giving people false expectations about human results.<p>[0] <a href="https://news.ycombinator.com/newsguidelines.html">https://news.ycombinator.com/newsguidelines.html</a>
“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.”<p>(In mice)
Algernon for Flowers.
I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon?<p>We have several drugs that emulate dementia in various ways and call them recreational.
Excellent news if you're a mouse.
The source paper:<p><a href="https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70232" rel="nofollow">https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...</a>
These billionaire mice are funding this research; humans should do the same
Was looking for the “in mice” in this article and found none… anybody got a link to the paper please
2.2 Animals and Study Design
The study comprised two cohorts of C57BL/6 mice: young adult (3 months old) and late middle-aged (18 months old). We chose 18 months old mice, as this mouse age is approximately equivalent to a 60-year-old human (Dutta and Sengupta 2016).<p>I posted paper above, DOI was linked at the end.
<i>Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus</i><p><a href="https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70232" rel="nofollow">https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...</a>
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Imagine the political implications of this if it actually worked.