9 comments

  • Vexs2 hours ago
    It&#x27;s worth reading this one to the end- the point of this paper isn&#x27;t about the math involved, it&#x27;s that this math was the result of the federal funding of maths research.<p>&gt; The cost-benefit ratio of Mathematical research has been off-scale. The Federal government spends about $250 Million&#x2F;year on mathematics research. Yet in the US there are 40 Million MRI scans per year, incurring tens of billions in Medicaid, Medicare and other Federal costs. The financial benefits of the roughly 10-to-1 productivity improvements now being seen in MRI could soon far exceed the annual NSF budget for mathematics research
    • rtkwe40 minutes ago
      It&#x27;s the thing people don&#x27;t get when they see odd studies being funded and try to judge if they&#x27;re worthy of being funded. Either it&#x27;s just they don&#x27;t understand where the study fits into a larger problem or simply that esoteric studies sometimes leads to surprising findings that are far more useful than anyone could reasonable predict.
    • CGMthrowaway29 minutes ago
      Sounds more like the point is that math research has high ROI compared to most federally funded research
      • WorkerBee2847410 minutes ago
        As the Soviets knew, apparatus are expensive but pencils are cheap.
  • yummybrainz3 hours ago
    If folks are interested, I recently published a paper [1] demonstrating that fMRI activity in the visual cortex is remarkably high-dimensional!<p>Specifically, using a linear approach (like PCA, but slightly fancier), we find that stimulus-related information is present along many, many dimensions of the neural response---much more than previously expected&#x2F;reported.<p>[1] <a href="https:&#x2F;&#x2F;journals.plos.org&#x2F;ploscompbiol&#x2F;article?id=10.1371&#x2F;journal.pcbi.1013714" rel="nofollow">https:&#x2F;&#x2F;journals.plos.org&#x2F;ploscompbiol&#x2F;article?id=10.1371&#x2F;jo...</a>
    • FL33TW00D3 hours ago
      Hasn&#x27;t fMRI as a whole been called into question? <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41593-025-02132-9" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41593-025-02132-9</a>
      • yummybrainz2 hours ago
        Yeah, there&#x27;s a ton of criticism of fMRI as a method, largely because of a lot of results that are statistically unsound (to say the least)!<p>I tend to think of fMRI data as some highly nonlinear transform of whatever neural activity is occurring in a particular region of the brain, at pretty coarse spatial resolution (~1-3 mm) and pretty bad temporal resolution (~5-15 s).<p>Sure, it&#x27;s no direct measure of neurons firing, but that doesn&#x27;t mean there isn&#x27;t <i>information</i> in the signal that we can interpret and maybe use (see [1] for a recent example of reconstructing seen images from brain activity)<p>As a cognitive neuroscientist, I tend to abstract away a ton of the details (neurons, molecules) and focus on more general computational principles: how do we get complex behavior from many simple interacting units---voxels in fMRI, for instance?<p>Regarding the specific paper you posted, I saw some of the discourse around it but haven&#x27;t read it carefully myself (it&#x27;s not my area of expertise). I saw some recent re-analysis of that data [2] that argues that the result isn&#x27;t valid, but need to look at it more carefully.<p>[1]: <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41598-025-89242-3" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41598-025-89242-3</a> [2]: <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.64898&#x2F;2026.04.21.719913v1" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.64898&#x2F;2026.04.21.719913v1</a>
        • djoldman28 minutes ago
          Could you share your thoughts about neuralink? Is there enough signal for this to really work?
          • yummybrainz8 minutes ago
            Caveat: brain-computer interfaces are not <i>quite</i> my field, but I think the consensus is (judging from some conversations with folks who know more):<p>Neuralink <i>is</i> doing interesting BCI research, with decent hardware, but it&#x27;s not really a step-change above and beyond the rest of the field.<p>There&#x27;s definitely a lot of promise in using BCIs for rehabilitation of patients with brain injuries but their input-output capabilities are still incredibly crude: for example, we can&#x27;t reliably &quot;write&quot; to the brain to make people perceive things beyond very simple stimuli (e.g. a phantom touch sensation, or a visual phosphene).<p>This is understandable: the brain has a bajillion neurons and we only have ~1,000 electrodes that aren&#x27;t particularly precise in how&#x2F;where they zap the brain---and even if they were, we don&#x27;t really know well enough how the brain works to &quot;control&quot; perception finely.<p>Other problems for BCIs include (i) &quot;representational drift&quot;, where the brain&#x27;s code changes over time, so you need to keep fine-tuning your interface in some sort of closed loop fashion and (ii) damage&#x2F;scarring to neural tissue.<p>&gt; Is there enough signal for this to really work?<p>I&#x27;m not quite sure what Neuralink&#x27;s marketing claims are, so I&#x27;m not sure what you mean by &quot;this&quot; here. But intracranial electrodes do have a surprising amount of signal, especially relative to non-invasive methods (I&#x27;m currently collecting some iEEG data myself!)<p>I really want the sci-fi future where we have brain-computer interfaces that augment our cognition and perception, but we&#x27;re nowhere close---though we&#x27;re getting better.
        • Lerc2 hours ago
          It sounds like it&#x27;s a claim along the lines that you can&#x27;t tell &quot;I love Lucy&quot; is on because you are listening to the audio and not looking at the screen.
          • CGMthrowaway27 minutes ago
            fMRI is a step above dowsing rods. It&#x27;s plugging a multimeter into an outlet and guessing what type and brand of appliances you are running in your house.
            • yummybrainz6 minutes ago
              I&#x27;d say you&#x27;re right about any given individual channel: the activation of a single voxel doesn&#x27;t tell us much about all the fancy computation happening in that ~1 mm^3 of tissue.<p>But the pattern of activity of thousands of voxels across cortex <i>does</i> contain reliable information! And a decent amount of it too, at least in sensory cortices.
            • fgfarben21 minutes ago
              Have you heard of time-domain reflectometry? A $20,000 multimeter could have the &quot;impossible&quot; feature you describe all but built in.
      • observationist2 hours ago
        fMRI is noisy, but there is definitely signal.<p><a href="https:&#x2F;&#x2F;medarc-ai.github.io&#x2F;mindeye&#x2F;" rel="nofollow">https:&#x2F;&#x2F;medarc-ai.github.io&#x2F;mindeye&#x2F;</a><p>Recent studies have demonstrated using fMRI data to reconstruct the images of what the person being scanned is seeing. There&#x27;s enough information there to produce a highly plausible reconstruction - if someone is seeing a picture of a zebra, the software shows a zebra, but it&#x27;s not going to get the stripe patterns exactly right.<p>fMRI provides a great proxy and noisy set of signals. Fortunately, the brain is redundant enough that a bunch of regions getting activated creates a sufficiently differentiable pattern at large that you can get enough good information to do things like MindEye and so on. Fortunately, recent AI breakthroughs have allowed extremely high dimensional geometry to be handled relatively simply, with millions or billions of dimensions being processed into semantically useful tools.
      • bonsai_spool3 hours ago
        &gt; Hasn&#x27;t fMRI as a whole been called into question? <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41593-025-02132-9" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41593-025-02132-9</a><p>I don&#x27;t immediately see how that paper&#x27;s assertion (that some areas&#x27; fMRI response is influenced by baseline oxygenation and cerebral blood flow) relate to the reliability of an information modeling experiment?
      • mattkrause2 hours ago
        I wouldn&#x27;t say &quot;called into question&quot;, as if the whole idea is bunk.<p>MRI is, in general, a lot harder than people often imagine. It uses complicated physics to measure convoluted physiological changes to indirectly measure brain activity, which is obviously stupifying involved--and then relate that to other, often complicated factors like behavior, lifestyle or disease state.<p>I think it&#x27;s reasonably well-known that the BOLD response is complex and doesn&#x27;t directly reflect &quot;average&quot; spiking activity. Some studies find that it&#x27;s sensitive to the amount of synchrony (=more neurons firing together in time) rather than the rate. The paper you mention shows another dissociation: neurons can get more fuel by extracting oxygen more efficiently OR have having more overall oxygen to extract at the same rate. Thus, it&#x27;s not noise, but it is complicated.
  • fcortes1 hour ago
    A couple of months ago I wrote a small post [1] (in Spanish) about subsampled MRI image reconstruction using compressed sensing and how it relates to government funding issues. At the time Tao had written some posts [2] about how the IPAM, where Terrence Tao was working, was losing some funding because UCLA wouldn&#x27;t follow some new federal government policies.<p>[1] <a href="https:&#x2F;&#x2F;fintualist.com&#x2F;chile&#x2F;ciencia&#x2F;los-efectos-de-las-polemicas-de-trump-con-las-universidades-el-caso-de-las-resonancias-magneticas&#x2F;" rel="nofollow">https:&#x2F;&#x2F;fintualist.com&#x2F;chile&#x2F;ciencia&#x2F;los-efectos-de-las-pole...</a> [2] <a href="https:&#x2F;&#x2F;mathstodon.xyz&#x2F;@tao&#x2F;114956840959338146" rel="nofollow">https:&#x2F;&#x2F;mathstodon.xyz&#x2F;@tao&#x2F;114956840959338146</a>
  • hansvm3 hours ago
    You can do a lot better than this if you redefine the problem from directly generating images with certain contrasts to maximizing information gain, even with weak magnets. They&#x27;ve since basically run out of money and are on life support, but Q Bio [0] had that tech working years ago, able to quickly derive many different image types from an entropy-maximizing scan, though they never deployed that in prod IIRC (again, they&#x27;re broke).<p>[0] q.bio
  • jeffreygoesto3 hours ago
    I remember one of my diploma students continued with discrete tomography as PhD, topic &quot;Binary Tomography by Iterating Linear Programs&quot; and I found it super interesting to get down the number of shots and at the same time increasing the accuracy a lot.
  • throwaway340182 hours ago
    Having worked through Geometric Tomography by Gardner, one of the big names in the field, I am pretty confident in asserting that the folks in the field have little to no interest in tomography or other applications. It&#x27;s merely a grant winning ruse. The same field rebrands as &quot;high dimensional probability&#x2F;stats&quot; by casting the uniform measure on convex bodies in the language of log-concave densities, but you talk to the folks themselves and they smirk about the extent to which they care about whether their work has any relation to the applications they claim.<p>There are some notable exceptions -- Donoho, Vershynin -- but most of them are doing good old fashioned Brunn-Minkowski theory, which is fundamental but a hard sell in its most truthful form.
  • davidkipstar3 hours ago
    It&#x27;s a nice review but the end reads like a funding pitch. The most important Mathematicians like donoho and Tao in the US seem to currently experience budget cuts and start to address the public.
  • Michael6664 hours ago
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  • tug20243 hours ago
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