The Biochemical Beauty of Retatrutide: How GLP-1s Work

(acesounderglass.com)

25 points by surprisetalk3 days ago

4 comments

caycep15 minutes ago
Author spent a ton of time writing this up "for fun"...but glad people are still doing this and old school blogs. The effort required seems substantial...Not sure about the AI style transfer images... sure it's a valid way to get the illustrations you want but I don't have to like it...
mchusma1 hour ago
Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to eat as much and you want to eat healthier. As far as I can tell, that is it. While I’m nervous there could be long term side effects, I think the health benefits of being at a healthy weight mean that for probably 50% of the developed world they would benefit from it.Looking forward to more formal studies though!
- jfreds29 minutes ago
 I tried semaglutide and while it was effective for losing weight, it made working out impossible (felt exhausted and very sick as soon as hr went up) and it made hangovers awful. Is retatrutide any different?
 - the_real_cher17 minutes ago
 I got food poisoning on a glp2 and it was the worst I've ever felt in my life for like a week because it it slows the digestion.it was an edge case I had not considered.
- nose1 hour ago
 How is everyone purchasing Retatrutide at this moment? It's still in phase 3 trials, and I keep hearing of people being on it. Not really seeing safe options with proper lab testing.Other pharmaceuticals at the phase 3 stage (such as Buntanetap for Parkinson's disease) are super difficult to get, even with the right to try exemption in the US.
 - elteto30 minutes ago
 Wellness/Health clinics sourcing from China or compounding pharmacies, which themselves source the ingredients from China.
 - antinomicus1 hour ago
 Yeah, I hear everyone talk about it like it’s just super easy to get…
 - bsamuels48 minutes ago
 they buy it from research peptide vendors
- icameron1 hour ago
 Does it alter you mind more than just your appetite for healthy food like you said? Is there a buzz or general mood lift as well?
 - cj1 hour ago
 If there's any mental effect, it's most likely from eating less food (and most likely healthier food) and feeling better because of that.It doesn't increase your appetite for healthy food. It will punish you for eating bad food. "Don't eat that steak, you're going to have crazy stomach pain tomorrow if you do!"
 - stavros39 minutes ago
 That's not my experience with tirzepatide. When it worked for me (which was a brief period, admittedly), it kind of turned me off fatty foods, and I wouldn't want to have pizza, for example, but I'd crave a chicken breast and boiled potato, or salad.When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it, which is the worst of both worlds. If I'm still going to be unable to resist food, I don't want to be punished for it any more than I already am by being overweight!
 - cj31 minutes ago
 > When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from itI saw this was a feature, not a bug.
 stavros23 minutes ago
 For me, it was definitely a bug, because my issue is I can't restrain myself. I don't lose weight, I just get pains. If I could restrain myself, why do I need the medication?
- stavros1 hour ago
 Unfortunately, my experience with tirzepatide doesn't make me hopeful: It either gave me terrible diarrhea and sulfur burps, or it did nothing at all, even on 15mg. Hopefully retatrutide is different, but I'm not holding my breath.It did work for around two weeks, though, and it was great. I constantly felt mildly carsick, so I didn't really want to eat anything, but also didn't have much trouble eating my macros.
 - zemvpferreira1 hour ago
 Sorry to hear that. As a counterpoint for the peanut gallery I've been on tirzepatide for 5 months and lost 15 kg in the first 3 months, never going past a 1.25mg dose. I've only creeped up to 3mg since and keep losing around 0.3 kg per week. No side effects except for super mild nausea every now and then. I plan to stay at a similar or lower dose for the next couple of years.I had the good fortune of responding well and being at a great starting point: despite being 40% body fat I exercised a lot and had great labs to begin with. Anecdotally I've found starting metabolic health to make a huge difference in dose response.
 - stavros1 hour ago
 Thanks, everyone else I know who's tried it has had great results, I guess I'm just unlucky :/
 - cj1 hour ago
 How did you get to 15mg and only had it working for 2 weeks? The starting dose is 2.5mg and it takes many months to titrate up to 15mg. Most people never get to 15mg.I've read hundreds of anecdotal experiences from people on these drugs, and haven't encountered anyone taking 15mg without success.
 - stavros1 hour ago
 > How did you get to 15mg and only had it working for 2 weeks?Shrug, it's a mystery to me as well. It did take many months to get to that point.
 - gedy1 hour ago
 Everyone is different but I lost over 40lbs just by taking 5mg over about 5 months
zoba1 hour ago
I hope it is more effective that Tirzepatide of which I am a rare nonresponder and have only gained weight.
aaron69537 minutes ago
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