Expansion Microscopy Has Transformed How We See the Cellular World

1 comments

• tmathmeyer3 hours ago
  Its a cool technology. I had a friend working on using expansion microscopy for neuron connectomics research. Apparently the route the lab was taking was introducing mutations to mouse brains that would cause protein expression that would physically color individual neurons at random, then using an optical microscope to view and trace neurons through an expanded sample.
  • katee3 hours ago
    E11 bio recently released <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2025.09.26.678648v1.full" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2025.09.26.678648v1....</a><p>There’s an animated version at <a href="https:&#x2F;&#x2F;www.e11.bio&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.e11.bio&#x2F;</a> and the dataset is publicly available: <a href="https:&#x2F;&#x2F;aws.amazon.com&#x2F;blogs&#x2F;publicsector&#x2F;unlocking-the-brains-secrets-e11-bios-brain-circuit-mapping-dataset-now-on-aws-open-data&#x2F;" rel="nofollow">https:&#x2F;&#x2F;aws.amazon.com&#x2F;blogs&#x2F;publicsector&#x2F;unlocking-the-brai...</a><p>That’s a big data application of expansion microscopy. I really enjoyed the charming smaller scale examples in the article.
    • tmathmeyer2 hours ago
      yes, E11 was the lab I was referring to :)