On chronic coffee consumption: "One meta-analysis found that RR coffee 0.757, RR caffeine 0.721 (12). Another one found RR 0.76, with an optimal protective effect at ∼400 mL/day (13). In comparison to many drug treatments that have an effect size in this range, this is not a small effect size. A risk reduction of 20 to 25% is quite impressive."<p>As if I needed another reason to drink coffee.
One thing I've learned over the years is that specifically setting out to enjoy and appreciate something on a daily basis is beneficial to overall satisfaction with life. And for me, that's my morning cuppa before the rest of the house wakes up. Is it (just) the coffee or is it (also) the rituals surrounding coffee?
>enjoy and appreciate something on a daily basis is beneficial to overall satisfaction with life.<p>I'll couch this in a warning that you need to have the money for it, but for me an espresso machine and good grinder was such a great investment.<p>It's this thing I appreciate a lot every day.<p>If you're a drip coffee person I guess this won't apply and you can save a few thousand. Although I'd still recommend getting a grinder (not necessarily an expensive espresso worthy one) and good beans then.
Drip coffee is amazing: A consistent grinder; fresh, light or medium roasted beans protected from oxidation; and a machine that heats the water to the correct brew temperature (190-195 F)is all you need.<p>The flavor profiles are akin to wines; no decanting required.<p>Extremely enjoyable in the early morning moments.
Espresso is my soft spot given my origins, but a good drip on paper filters (to remove some oils and cholesterol) is akin to good tea, full of aromatics. I disagree with the temperature, for me a blonde roast calls for 72 degrees Celsius (162F).
Father of three here. I also enjoy very much this moment of the day, the calm before the storm. It was a real motivation to wake up a bit earlier.<p>One day, I decided to stop coffee for some weeks. My motivation to wake up before my kids vanished in a few days. I was quite surprised since it used to be a real pleasure. I guess the ritual part was much less important than the coffee chemical role.<p>I got back to coffe quite rapidly.
Did you just remove the warm drink part of the ritual or did you replace the coffee with another warm drink? This could be the big difference you were missing.
For me, it’s the reward after the storm – once everyone has gone I sit there and enjoy my coffee.
Is it the addictive substance or the ritual I created around it?<p>I used to think this same thing, that my enjoyment of coffee was largely the ritual. But then I switched to decaf for quite a long time and all my little rituals fell away quite quickly.<p>I still occasionally drank coffee when I felt like the taste, but I certainly wasn’t performing daily morning ritual.
It could also be that the decaf wasn't good? A lot of decaf is poorly roasted and tastes wrong.
I’ve switched to decaf full time and a my generalised anxiety basically went away. I love coffee and still drink it ritualistically. I probably drink more coffee now, at all hours of the day (caffeinated coffee after 12 really messed my sleep).<p>Also once per week I allow myself an espresso, and I get a nice buzz from it that lasts the entire day.
It's both. In stronger drug addictions, the ritual itself is rewarding even if there are no drugs present in your system yet.<p>Add that to conditioned place preference and you have your rewarding coffee ritual.
One could say the same about any drug. :D<p>I try to not let taste or smell overrule other decisions made by my brain. Of course it is so visceral that one can not escape it; some stinky fish challenges show how powerful smell is. Some people can not control their body's reactions to bad smell.
I've always associated this sort of life satisfaction & ritual spectrum with Zen "no-mind" [^1]<p>Whether it's coffee ritual, or doing dishes there's something pretty magical about the quiet flow state of engaging with the moment<p>[^1]: <a href="https://en.wikipedia.org/wiki/No-mind" rel="nofollow">https://en.wikipedia.org/wiki/No-mind</a>
It’s 100% the addiction.<p>It’s ok, me too. At home I’m a 4-6 cup a day drinker. On the go 2-3 Starbucks. I have a serious problem.
That was me too. Turns out I was just self-medicating for adhd. I still skip the meds on the weekend so I can enjoy larger quantities of coffee.
I'm not gonna lie, double espresso with ritalin before work is pretty good too. It's the T+2 date which is uncool.
That’s the ritalin. Find a healthier alternative like an energy bar with that double espresso. I find if I stack too much at once, I crash. One cup in the morning when I wake up. One before work right before the meetings. One in the afternoon to keep me fueled until dinner where I let myself gorge on protein and sugars until I crash.
Ritalin is a highly addictive substance that wrecks you, your life and the life of everyone around. Unfortunate that we have one in family.
Same. During the week on meds I find that drinking more than half a litre just provokes unpleasant sweating and makes me feel frantic, some amount of brain fog and occasionally a mild headache, especially if I haven't been chugging water, which I guess is probably what most normal people get from coffee
People act like addiction is a word with an inherent negative connotation, but that's not the case, you can totally be addicted to healthy behaviours
I don't want to get too deep into caffeine addiction so I drink mostly decaffeinated coffee. Am I just cheating myself?
Well, that's a bit of an unfair projection; I'm fairly fastidious about keeping my consumption around 2-3 cups a day before 11am and taking occasional tolerance breaks without consequence. But if you feel like your coffee intake is a problem that you have trouble controlling, maybe cut back.
Addiction to any given substance is highly variable from person to person, and there's a lot of data to back that up.<p>I recall a friend describing their struggle to quit caffeine, which I mocked at first, until I realized it sounded exactly like my brutal struggle to quit nicotine. Yet, plenty of people quit cigarettes effortlessly. Nicotine is one of the most variable, but caffeine, alcohol and cocaine vary widely too. I imagine we'd find this is the case for most substances if we had the data. In a sane world, we'd give every kid their addiction predisposition profile when they turn 13.
The hardest part of quitting <i>anything</i> is changing the behavioral habits that came with it.<p>For smoking, I bet you have the urge after a meal to smoke. Maybe you’re triggered when you drive long distances to “calm the nerves”. The issue is those triggers, those behaviors, need to be unlearned before you can attempt to quit. That’s why it’s easy for people who haven’t developed those behavioral habits and hard a hell for those who have. Former smoker myself so I totally get it. I can give that up, but caffeine - coffee? I’ll die with a cup on the counter half full.
The literature on this is clear cut. People absorb, metabolize and experience drugs differently, which has a big impact on how addiction takes hold. It's obviously not the only factor! But it's a big one and somewhat quantifiable.<p>Personally, I wasn't a "trigger" smoker, I was an "every chance I got smoker". I assume my nicotine metabolism is higher than average, which is linked to frequency of consumption and hence propensity for addiction. I also assume I have fast caffeine metabolism since I consume it at all hours with no consequence, but unlike nicotine that's linked to a lower propensity for addiction, which matches my experience.
Not necessarily. I only have one cup in the morning, that's it, but I enjoy it just the same so long as the beans are good and it's done right.
Caffeine is not chemically addictive. It can lead to depedency but that is not addiction. Motivation and wanting are not altered but unpleasant withdrawl effects can occur.
There is no real importance to the concept of “chemically addictive” and it has largely gone out of favor in psychology. Even physical behaviors like gambling and sex that obviously cannot directly, chemically act on reward system pathways, can still be just as life destroying addictive and challenging to quit as any drug. The dsm now classifies gambling disorder as an addiction.
Caffeine, unlike some drugs and alcohol, doesn't cause severe withdrawal symptoms. Because of that, experts don't label regular caffeine use as an addiction.<p><a href="https://www.webmd.com/diet/caffeine-myths-and-facts" rel="nofollow">https://www.webmd.com/diet/caffeine-myths-and-facts</a>
There’s so many layers to this. First, there’s history: Coka-cola (originally made from a Kola nut and cocaine) was told they couldn’t put cocaine in their “medicine” anymore so they just sold it as a “soft-drink” without the cocaine.<p>Then there’s the beverage industry who pointed out there’s caffeine in tea leaves and other plant material and that it’s not a threat: (1) US vs 40 barrels and 20 kegs of Coka-cola. Ultimately reducing the amount of caffeine in soft-drinks.<p>Round and round we go allowing companies to use chemicals to keep us buying their consumables.<p>(1) <a href="https://en.wikipedia.org/wiki/United_States_v._Forty_Barrels_and_Twenty_Kegs_of_Coca-Cola" rel="nofollow">https://en.wikipedia.org/wiki/United_States_v._Forty_Barrels...</a>
While it is a contributing factor, physical dependence- withdrawal is not anymore considered necessary or sufficient for addiction. The author there is using an outdated pre-DSM5 definition of addiction which failed to recognize that there are two separate but related phenomena here. Things like gambling and sex addiction obviously cause no withdrawal symptoms from chemical dependence at all, but can be almost impossible to quit and serious enough to destroy someone’s life.<p>Severity of withdrawal symptoms from caffeine also varies substantially from person to person. It’s probably not directly killing anyone, but for some people it can be brutally unpleasant and disabling for at least several days.
What’s the point of this distinction, what does it mean that it’s not chemically addictive? It causes withdrawals, dependence, it definitely acts on brain chemistry.
How do you explain the headaches and exhaustion durring withdrawal then?
That's just how life feels without caffeine, not a withdrawal effect.
Caffeine withdrawal takes 2 days.<p>The explanation for the headaches is that coffee raises blood pressure short term, and the blood vessels in the brain prepare for the predicted caffeine ingestion, and if it doesn't come there will be a mismatch.
That's called chemical dependence and it's the point I'm trying to make. Dependence is not addiction. Addiction means wanting is hijacked, not that stopping is aversive.<p>Addiction and dependence have real medical meanings and in the context of this discussion and we shouldn't mix them up. See this very short and to the point lancet medical journal summary, <a href="https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(2300230-4/fulltext" rel="nofollow">https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0...</a><p>>Addiction (synonymous with substance use disorder), as defined by the DSM-5, entails compulsive use, craving, and impaired control over drug taking in addition to physical dependence. The vast majority of patients taking medications such as opioids and benzodiazepines are doing so as prescribed by clinicians, with only 1·5% of people taking benzodiazepine being addicted, for example. Physical dependence is much more common than addiction. Importantly, withdrawal effects occur irrespective of whether these drugs are taken as prescribed or misused.<p>>Failure to distinguish between addiction and physical dependence can have real-life consequences. People who have difficulty stopping their medications because of withdrawal effects can be accused of addiction or misuse. Misdiagnosis of physical dependence as addiction can also lead to inappropriate management, including referral to 12-step addiction-based detoxification and rehabilitation centres, focusing on psychological aspects of harmful use rather than the physiology of withdrawal.<p>>It should be made clear that dependence is not the same as addiction. The problems with prescribed drug dependence are not restricted to the small minority who are misusing or addicted to these drugs, but to the wider population who are physically dependent on and might not be able easily to stop their medications because of withdrawal effects. Antidepressants (superkuh note: and caffeine) should be categorised with other drugs that cause withdrawal syndromes as dependence-forming medications, while noting that they do not cause addiction.
I used to have withdrawal symptoms when I didn't have coffee, now I don't have those. But yes, the alone time in the morning is critical for me.
I also enjoy my morning ritual of preparing the grinds and brewing a fresh pot. But I'll be honest, at the end of the day it doesn't really matter where I get it -- brunch at a nice restaurant, Starbucks, McDonalds, a cheap hotel buffet, lukewarm from a flight attendant ... as long as I get it. Sounds healthy, right?! ;)
Ah yes, the Twin Peaks method
My wife and I don't drink caffeine anymore but still have a swiss water decaf coffee every morning.<p>The caffeine aspect is completely unnecessary, but coffee still tastes good, warm drinks are still nice. It's all the ritual.
One thing you learn from reading depression papers is that there are a lot of things that supposedly have significant effects on depression according to some papers, but then fail to work when people try them or they’re tested in trials.<p>The linked paper is pretty obvious AI paper mill content, so I wouldn’t take anything it says as directly true without checking citations. The citation is a meta-analysis so you’d have to check the criteria and the studies.<p>The most common explanation for the “everything treats depression” result is inclusion of studies that have no control group. The placebo response rate in depression studies is very high as many patients revert to the mean of being not-super-depressed after they are so depressed that they enroll in a study for depression treatments. Paper writers seeking a positive result will abuse this to their benefit by omitting the control group. They’ll collect depressed patients, give them some treatment, and when the average improves they’ll publish a paper saying that the treatment has positive effects in depression. So after reading a lot of papers about depression, you start dismissing claims by default unless you can confirm they came from a properly powered, placebo-controlled, double-blind study.<p>But hey, if you’re already drinking coffee and enjoying it, continue to enjoy it!
> As if I needed another reason to drink coffee.<p>I tried it but coffee to me just tastes horribly bad. Chocolate on the other hand can be quite great (there is also a lot of horrible chocolate, but good chocolate has a better taste to me than coffee.)
I like espresso-style coffee. Over the years i discovered that the very best espresso shots do have a rather strong chocolate note. No acidity, no bitterness.<p>Unfortunately I also found out that it is basically impossible to get that kind of quality from coffee shops. You must make it yourself, have the right equipment (the grinder is the most important one) and a lot of practice. Then you might have one in 10 god shots... but you taste it... you immediately recognize it.
How were you drinking it?
Espresso with steamed milk, sugar, and flavored syrup is quite a treat.<p>Drip, black, is going to be quite... utilitarian.
An espresso is about 30 ml of liquid... I am not sure this mixture of milk and sugar (and more sugar!) into 30 ml can still be called a "coffee" , but i'm sure it is a delicious beverage!
If by utilitarian you mean delicious, yes
How about a reason to cycle your coffee :)<p><a href="https://rouvy.com/blog/caffeine-in-cycling" rel="nofollow">https://rouvy.com/blog/caffeine-in-cycling</a><p><i>Caffeine periodization in cycling: the science behind performance</i> (2025)
I don’t have hard data, but I think this optimal value is very closely approximated by coffee drinkers’ daily average. 400 ml is about 1.75 cups, and i think the normal distribution of coffee cups among drinkers is centered at ~2 cups. Makes me wonder if we’re all self medicating and accidentally finding the sweet spot.
Hmm to feel a bit elevated makes sense. I also have that with one glass of alcohol at certain times. Heart rate goes up, things get a bit more intense. It's a nice vibe if you're open to it. It's also a bit subtle.<p>For me what I've noticed: 2 cups hits the spot, but I always tend to drink more, around 4 cups. On the 3rd cup my mind gets jittery. It's not so much my body or anything and I don't experience the jitters strongly but at the same time I feel a stronger focus while noticing that stronger focus isn't getting anything extra done. Hence I call it mind jitters.<p>But I can imagine that at 2 cups people are genuinely just a bit elevated in certain ways.
OR it could be that we find the sweet spot because it's the spot we feel the best.
Well, that's the hardest data of all!
The problem is, most Americans don't drink coffee, they drink sugary mix with coffee flavor
IMHO Coffee is way too strong for most of us. Sipping green tea gives a smooth subtle high all day. And you can sleep at night. And not be an angry/anxious bastard.
Yea high quality Japanese green tea has been my go to. Unfortunately, I'm addicted to coffee. Thank god I'm also lightly addicted to living frugally and that is currently winning out. Black tea for 20 bags for 35 cents it is.
I love coffee, I take 100mg L-theanin daily so my body tolerates it. Basically best of both worlds.
To add something constructive:<p>I've used a novel nootropic which is an adenosine antagonist (KW-6356) for long-lasting energy without dopaminergic stimulation. Something I found and which is commonly reported by other users is mood-enhancing properties:<p><a href="https://en.wikipedia.org/wiki/Sipagladenant" rel="nofollow">https://en.wikipedia.org/wiki/Sipagladenant</a>
"The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism"<p>More evidence for Chris Palmer's 'Metabolic Theory of Mental Disorders'
Maybe this is normal for mice but the dose of ketamine used (5-20 mg/kg) seems high? I know mice metabolism is very different but that's in the range of a gram of ketamine for a normal sized human.<p>The mice may not have been depressed because it's hard to be depressed when you're in a k hole
This appears to be some kind of AI-slop rapid response to a piece of actual research (over at <a href="https://www.nature.com/articles/s41586-025-09755-9" rel="nofollow">https://www.nature.com/articles/s41586-025-09755-9</a> ). I don't mind discussing that, but this piece should never have been published. Just look at Figure 2 if you don't believe me, or the publication timeline.
Agreed. It even has the classic “this not that” and “from this to that” LLM tells in the headline.<p>I would suggest ignoring this document and reading the Nature article linked in the comment above.
Glad I wasn't the only one to suspect AI slop. The language is too self promoting and vacuous in parts. Just doesn't feel like a human wrote it to me.
I never knew that “acute intermittent hypoxia” was a known treatment for depression, but I’ve found both freediving and Wim Hof breathing to be effective at treating my depression- however never the two at the same time as that is extremely dangerous.
Completely anecdotal but I've found Ujjayi Breathing from yoga to have an enormously calming effect.<p>Long exhales in general with a short pause at the end, before inhaling, are also incredibly useful. I try to do this as often as I need.
I’ve found wim hof no more effective than laughing gas. Very short euphoric high then back to where I was plus a slight headache.
I suspect you’re missing something important- not surprising since Wim is a really unclear teacher. The low oxygen and/or high co2 causes your body to panic and you are supposed to use that as a stimulus to gradually train conscious control of your heart rate and stress response and calm yourself down. This is where the benefit comes from, not the short term physiological panic itself, whose symptoms you are describing. In fact, those symptoms should go away entirely when you learn to calm the panic and consciously control your autonomic nervous system. This then also primes you mentally to be able to go into ice water, which is also a large stimulus to learn to calm, plus trains your brain to more easily jump into anything difficult. All of this takes months or years of consistent practice to gradually develop a relatively permanent sense of calm and internal strength among other things, and is really just a simplified form of tantric tummo meditation.
Then again, Wim Hof costs you $0 and laughing gas gets expensive.
> applied GRABAdo1.0, a GPCR-based sensor for adenosine<p>At first the intro was:<p>> Using genetically encoded adenosine sensors<p>And I did not know what was meant with that. Lateron this
became more clear - GPCR is a common motif for membrane-based
receptor systems. <a href="https://en.wikipedia.org/wiki/G_protein-coupled_receptor" rel="nofollow">https://en.wikipedia.org/wiki/G_protein-coupled_receptor</a><p>So, saying it is "genetically encoded" xyz, means absolutely
NOTHING at all, because all the other receptors based on GPCR
(see the wikipedia article) are ALSO "genetically encoded". After
all some stretch of DNA yields mRNA which in turn is translated
into the corresponding aminoacid sequence (= protein), if we ignore
splicing and so forth to simplify this (and then transport into the
membrane). This is supposed to be a scientific article though - why
do they use such a strange terminology e. g. "genetically encoded"?
I mean, this follows by simple logic unless it was made completely
artificially. Lateron in the article it is more clear, but it is
strange that they use those words in the summary-intro part. It almost
seems to me as if they wanted to integrate certain keywords as
buzzwords or to rank an article higher. I don't quite like that.<p>Contrast this to Watson and Crick from 1953:<p>"It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material."<p>It is probably one of the most famous intro lines, e. g. the
"It has not escaped our notice" since it was so casual. (And they built
their insights on data of others, so it wasn't just Watson and Crick to
have made the discovery; not even only Franklin etc.. but several more
that should have been credited with it. Watson and Crick's main achivement
here was more that they built it together into a simple, cohesive overview
and explanation model. If I recall correctly, Linus Pauling also came close
but proposed three helices.)
> This is supposed to be a scientific article<p>The 'article'[1] is completely written by an LLM.<p>1. <a href="https://genomicpress.kglmeridian.com/view/journals/brainmed/aop/article-10.61373-bm025c.0134/article-10.61373-bm025c.0134.xml" rel="nofollow">https://genomicpress.kglmeridian.com/view/journals/brainmed/...</a> currently, hopefully it is changed to the actual research link which is <a href="https://www.nature.com/articles/s41586-025-09755-9" rel="nofollow">https://www.nature.com/articles/s41586-025-09755-9</a>
It'd be extraordinary compelling to genuinely have a unified mechanism to explain depression treatments, but I am not qualified to make heads or tails of the research. Wondering what the take of those with relevant experience is on this?
Not an expert, but the standout thing about ketamine in particular is that it targets an entirely different neurotransmitter pathway than almost all traditional anxiety and depression meds. Traditionally, people treating serious depression or anxiety rotate through a variety of drugs that all hit same small set of neurotransmitters and settle on the one that works the best/sucks the least.<p>This is why people get excited about ketamine and psychedelics as therapeutics. Otherwise, we're just sitting around waiting for the next round of "new" drugs that manipulate the same pathways as all the old drugs (and carry much of the same risks).
Wholly anecdotal, but as a 52 year old nearly-lifelong caffeine (ab)user I quit this year and the withdrawal period was horrendous -- not for the headaches everyone knows about (they were bad but only lasted a couple of days) but for the somewhat extended depression/anhedonia which I had never really experienced before.<p>I was worried during that stretch of time that maybe the caffeine had been masking some underlying depression I already had, but a couple of weeks in it passed, so I think my brain just needed to rebalance itself to the new caffeine-free reality.<p>I'm glad I quit (less anxiety, better sleep, I'm finding it a lot easier to eat healthy while not buzzed on caffeine all the time, and the depressive episode was temporary) but going through that makes it pretty easy for me to believe caffeine can have rather powerful effects in this area.
I think a lot of the difficulty in quitting can be mitigated by slowly titrating down the dose over a month or two instead of quitting cold turkey.<p>But your experience mirrors mine in going cold turkey which I think demonstrates that caffeine can cause both physical chemical dependence, and psychological addiction.
Nice read, I've been wondeling if coffee really had an effect on mental health too
It seems that a session like 10×100 m sprints with <90 seconds of rest produces a metabolic pattern very similar to acute intermittent hypoxia, short intense bouts with incomplete recovery. Am I thinking about this right?
This also helps explain why extremely early waking or late sleeping is common in depression.
TIL coffee is extra good for your brain