Sky's the limit. (Short of hiring a team of engineers to design and fab a one-off board, anyway).<p>I appreciate your advice. I use the machine for a variety of different tasks, and am looking to accommodate at least two high-end GPU's (1 for passthrough to virtual machines for running things like Solidworks), a number of SSD's, and as many PCIe expansion cards as possible. Many of the cards are older-gen, so could be consolidated to just a few modern lanes if I could find an external expander with sufficiently generous capacity. Here's a quick inventory of what's in the existing box:<p>- Mellanox Infiniband. For high-speed, low-latency networking... these days, probably replaceable with integrated NIC's, particularly if they come with RDMA.<p>- High-performance RAID. I've found dedicated cards offer better features, performance, capacity, resilience and reliability than any of the mobo-integrated garbage I've tried over the years. Things like BBU's/SuperCaps, seamless migration and capacity upgrades, out-of-band monitoring, etc. e.g. I've taken my existing mass storage array created on a modest ARC-1231ML 15+ years ago, through several newer generations to an ARC-1883, with many disk and capacity upgrades along the way, but it's <i>still the same array</i> without ever having had to reformat and restore from scratch. Incidentally I've been particularly happy with Areca's hardware, and they've even implemented some features I requested over the years (like the ability to hot-clone a replacement disk for one expected to fail soon then swap in the new one, without having to degrade the array and wait for a lengthy rebuild process that reduces your fault tolerance while hammering all member disks; as well as some other tweaks for better compatibility with tools like Hard Disk Sentinel). I notice they're finally starting to come out with controllers oriented to SSD's, like a PCI 5.0 product (<a href="https://www.areca.com.tw/products/nvme-1689-8N.html" rel="nofollow">https://www.areca.com.tw/products/nvme-1689-8N.html</a>) for up to 8 x4 M.2 SSD's that boasts up to 60 GB/s, which is interesting (though the high-queue-depth random performance still doesn't match directly-plugged drives). I know software-RAID for the solid state stuff is also an option (as is just living without redundancy), but it's been convenient outsourcing the complexity.<p>- Slim, low-performance accessory GPU for more displays<p>- A few others this crowd would just laugh at me for (e.g. a PCI I/O card that includes a true parallel port, because nothing is more fun™ for hobbyist stuff and USB-based alternatives were found to have too much abstraction or latency; a SCSI adapter for an archaic piece of vintage hardware I'd love to keep installed permanently but there ain't space, and occasional one-off use stuff like a high-bandwidth digitizer).<p>The motherboard had 6 PCIe slots, and I've got two more provided by an external PCIe expander (after accounting for the one lost for it's own connection). If I could find some kind of expander that took a single PCIe 5.0 slot and turned it into half a dozen PCIe 3.0 slots (some full-width) I'd be set.<p>I know I'm at the crazy end of how-much-crap-can-you-jam-in-one-PC, but it still seems bizarre to me that newer boards have so many fewer slots yet feel lane-constrained, when between leading-edge SSD's and high-bandwidth GPU's the demand for more lanes is skyrocketing. When I built the previous PC it felt tight but doable... these days it feels like I can barely accommodate the level of graphics and storage I'd like, and by the time I do, there's nothing left for anything else. Granted it's been a few years since I got my hands dirty with this stuff, so maybe I'm just doing it wrong?<p>And yes, I've heard of USB... and have a bazillion devices plugged in (including some of exotic ones like an LCD display, logic analyzer, and a <i>legit</i> floppy drive that does get used once in a blue moon like when I need to make a memtest86 boot disk for a vintage PC). I've actually found some motherboards have issues where the USB stack gets flakey once you have too many devices connected (even using powered hubs to mitigate power constraints).<p>Ok... go ahead and have at me; tell me I'm old and dusty and I should take my one GPU and one SSD and be happy with them ;-).